Core Technology

NEWGLAB Core Technology

One of the missions of NewG Lab Pharma
(NGLP) will be to develop novel anticancer
therapeutics that extend the life of cancer patients
without compromising the quality of life.

Papers

  • High aerobic glycolysis of rat hepatoma cells
    in culture: Role of mitochondrial hexokinase

    Ernesto Bustamante & Peter L. Pedersen / 1977
    / Biochemistry

  • Tumor Mitochondria and the Bioenergetics of Cancer Cells

    Peter L. Pedersen / 1978

  • Hexokinase Receptor Complex in Hepatoma Mitochondria: Evidence from N,N'
    -Dicyclohexylcarbodimide-Labeling Studies for the Involvement of the Pore-Forming Protein VDAC?

    Richard A. Nakashima/ 1986 / Biochemistry

  • Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase

    Ko YH, Peter L. Pedersen, J.F. Geschwind/ 2001 / Cancer Letters

  • Novel Therapy for Liver Cancer: Direct Intraarterial Injection of a Potent Inhibitor of ATP Production

    Geschwind J-FH, Ko YH, Torbenson MS, Magee C. Pedersen PL. / 2002 / CANCER RESEARCH

  • 3-bromopyruvate (3BP) a fast acting, promising, powerful, specific, and effective “small molecule” anti-cancer agent taken from labside to bedside: introduction to a special issue

    Peter L. Pedersen / 2012 / Journal of Bioenergetics and Biomembranes (Springer)

  • A Translational Study "Case Report" on the Small Molecule "Energy Blocker" 3BP as a Potent Anticancer Agent: From Bench Side to Bedside.

    Ko, YH / 2012 / Journal of bioenergetics and biomembranes

  • The energy blockers bromopyruvate and lonidamine lead GL15 glioblastoma cells to death by different p53-dependent route

    Magdalena Davidescu /2015 / Nature Scientific Reports

  • The HK2 Dependent “Warburg Effect” and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate

    Paweł Lis , Mariusz Dylag , Katarzyna Niedzwiecka ,
    Young H. Ko, Peter L. Pedersen, Andre Goffeau
    and Stanisław Ułaszewski / 2016 / Molecules 

  • Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention

    Peter L. Pedersen, Saroj Mathupala, Annette Rempel,
    J.F. Geschwind, Young Hee Ko / 2002 /Biochimica
    et Biophysica Acta

Including 3rd Parties
Cancer type In vitro In vivo
Breast
Buijs et al. 2013
Liu et al. 2009
Verhoeven and van Griensven 2012
Birsoy et al. 2013
Queiros et al. 2012
Cardaci et al. 2012
Thangaraju et al. 2009
Mouse
Rat
Birsoy et al. 2013
Buijs et al. 2009
Buijs et al. 2013
Wu et al. 2014
Cervix
Cardaci et al. 2012
Colorectal
Chen et al. 2009
Yun et al. 2009
Ihrlund et al. 2008
Zhou et al. 2012
Sanchez-Arago and Cuezva 2011
Endometrium
Byrne et al. 2014
Mouse
Byrne et al. 2014
Gastric Mouse
Xian et al. 2014
Glioblastoma
Davidescu et al. 2012
Macchioni et al. 2011
El Sayed et al. 2012b
Wicks et al. 2015
El Sayed et al. 2012c
Rat
Wicks et al. 2015
Hepatic
Ganapathy-Kanniappan et al. 2010a
Ganapathy-Kanniappan et al. 2012
Pereira da Silva et al. 2009
Yu et al. 2011
Gong et al. 2014
Kim et al. 2008
Rodrigues-Ferreira et al. 2012
Mouse
Rat
Rabbit
Ganapathy-Kanniappan et al. 2012
Gong et al. 2014
Ko et al. 2004
Geschwind et al. 2002
Kim et al. 2007
Vossen et al. 2008
Yu et al. 2012
Kidney
Nilsson et al. 2015
Leukemia
Chen et al. 2009
Hulleman et al. 2009
Verhoeven and van Griensven 2012
Lung
Zhang et al. 2012
Mouse
Zhang et al. 2012
Lymphoma
Chen et al. 2009
Schaefer et al. 2012
Mouse
Schaefer et al. 2012
Melanoma
Qin et al. 2010
Verhoeven and van Griensven 2012
Mesothelium
Icard et al. 2012
Mouse
Icard et al. 2012
Myeloma/
Myeloid
Leukemia
Calvino et al. 2014
Majkowska-Skrobek et al. 2014
Nakano et al. 2012
Neuroblastoma
Matsushita et al. 2012
Ovarian cancer
Wintzell et al. 2012
Pancreas
Bhardwaj et al. 2010
Xiao et al. 2013
Chapiro et al. 2014
Ota et al. 2013
Mouse
Chicken eggs
Cao et al. 2008
Isayev et al. 2014
Isayev et al. 2014
Chapiro et al. 2014
Ota et al. 2013
Prostate carcinoma
Cardaci et al. 2012
Squamous cell carcinoma
Matsumoto et al. 2013
Mouse
Matsumoto et al. 2013